|Other Names||RalA-binding protein 1, RalBP1, 76 kDa Ral-interacting protein, Dinitrophenyl S-glutathione ATPase, DNP-SG ATPase, Ral-interacting protein 1, RALBP1, RLIP1, RLIP76|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin.|
|Cellular Location||Membrane; Peripheral membrane protein|
|Tissue Location||Expressed ubiquitously but at low levels. Shows a strong expression in the erythrocytes|
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Provided below are standard protocols that you may find useful for product applications.
RALBP1 plays a role in receptor-mediated endocytosis andis a downstream effector of the small GTP-binding protein RAL (seeRALA; MIM 179550). Small G proteins, such as RAL, have GDP-boundinactive and GTP-bound active forms, which shift from the inactiveto the active state through the action of RALGDS (MIM 601619),which in turn is activated by RAS (see HRAS; MIM 190020) (summaryby Feig, 2003 [PubMed 12888294]).
Singhal, S.S., et al. Int. J. Cancer 126(6):1327-1338(2010)Singhal, S.S., et al. Cancer Lett. 283(2):152-158(2009)Awasthi, Y.C., et al. J Toxicol Environ Health B Crit Rev 12(7):540-551(2009)Singhal, S.S., et al. Cancer Res. 69(10):4244-4251(2009)Singhal, S.S., et al. Biochem. Pharmacol. 77(6):1074-1083(2009)
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