|Other Names||Collagen alpha-1(X) chain, COL10A1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Type X collagen is a product of hypertrophic chondrocytes and has been localized to presumptive mineralization zones of hyaline cartilage.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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This gene encodes the alpha chain of type X collagen, ashort chain collagen expressed by hypertrophic chondrocytes duringendochondral ossification. Unlike type VIII collagen, the othershort chain collagen, type X collagen is a homotrimer. Mutations inthis gene are associated with Schmid type metaphysealchondrodysplasia (SMCD) and Japanese type spondylometaphysealdysplasia (SMD).
Makitie, O., et al. J. Orthop. Res. 28(11):1497-1501(2010)Wang, S., et al. Connect. Tissue Res. 51(3):188-196(2010)Videman, T., et al. Arthritis Rheum. 60(2):470-481(2009)Higashikawa, A., et al. Arthritis Rheum. 60(1):166-178(2009)Zimmermann, P., et al. Arthritis Rheum. 58(9):2743-2753(2008)
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