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SF3B4 Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q15427
Clone Names 100525304
Peptide ID 100525304
Additional Information
Gene ID 10262
Other Names Splicing factor 3B subunit 4, Pre-mRNA-splicing factor SF3b 49 kDa subunit, SF3b50, Spliceosome-associated protein 49, SAP 49, SF3B4, SAP49
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SF3B4
Synonyms SAP49
Function Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. SF3B4 has been found in complex 'B' and 'C' as well. Belongs also to the minor U12- dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes one of four subunits of the splicingfactor 3B. The protein encoded by this gene cross-links to a regionin the pre-mRNA immediately upstream of the branchpoint sequence inpre-mRNA in the prespliceosomal complex A. It also may be involvedin the assembly of the B, C and E spliceosomal complexes. Inaddition to RNA-binding activity, this protein interacts directlyand highly specifically with subunit 2 of the splicing factor 3B.This protein contains two N-terminal RNA-recognition motifs (RRMs),consistent with the observation that it binds directly to pre-mRNA.


Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008)Rikova, K., et al. Cell 131(6):1190-1203(2007)Watanabe, H., et al. J. Biol. Chem. 282(28):20728-20738(2007)Wu, C., et al. Proteomics 7(11):1775-1785(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :

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$ 80.00
Cat# BP19396c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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