|Other Names||Neurotrophin receptor-interacting factor homolog, Zinc finger protein 274, Zinc finger protein HFB101, Zinc finger protein with KRAB and SCAN domains 19, Zinc finger protein zfp2, Zf2, ZNF274, ZKSCAN19|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin- modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610).|
|Cellular Location||Cytoplasm. Nucleus, nucleolus|
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This gene encodes a zinc finger protein containing fiveC2H2-type zinc finger domains, one or two Kruppel-associated box A(KRAB A) domains, and a leucine-rich domain. The encoded proteinhas been suggested to be a transcriptional repressor. It localizespredominantly to the nucleolus. Alternatively spliced transcriptvariants encoding different isoforms exist. These variants utilizealternative polyadenylation signals.
Wu, C., et al. Proteomics 7(11):1775-1785(2007)Sripathy, S.P., et al. Mol. Cell. Biol. 26(22):8623-8638(2006)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Yano, K., et al. Genomics 65(1):75-80(2000)Casademunt, E., et al. EMBO J. 18(21):6050-6061(1999)
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