|Other Names||Integrin-linked kinase-associated serine/threonine phosphatase 2C, ILKAP, ILKAP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Protein phosphatase that may play a role in regulation of cell cycle progression via dephosphorylation of its substrates whose appropriate phosphorylation states might be crucial for cell proliferation. Selectively associates with integrin linked kinase (ILK), to modulate cell adhesion and growth factor signaling. Inhibits the ILK-GSK3B signaling axis and may play an important role in inhibiting oncogenic transformation.|
|Tissue Location||Widely expressed. Highest levels expressed in striated muscle. Much lower levels evident in various smooth muscle tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
firstname.lastname@example.org, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a proteinserine/threonine phosphatase of the PP2C family. This protein caninteract with integrin-linked kinase (ILK/ILK1), a regulator ofintegrin mediated signaling, and regulate the kinase activity ofILK. Through the interaction with ILK, this protein may selectivelyaffect the signaling process of ILK-mediated glycogen synthasekinase 3 beta (GSK3beta), and thus participate in Wnt signalingpathway.
Nakrieko, K.A., et al. Cell Cycle 7(14):2157-2166(2008)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Hillier, L.W., et al. Nature 434(7034):724-731(2005)Kumar, A.S., et al. Oncogene 23(19):3454-3461(2004)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at email@example.com.