|Other Names||Cystinosin, CTNS|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Cystine/H(+) symporter thought to transport cystine out of lysosomes. Plays an important role in melanin synthesis, possibly by preventing melanosome acidification and subsequent degradation of tyrosinase TYR.|
|Cellular Location||Isoform 1: Lysosome membrane; Multi-pass membrane protein. Melanosome|
|Tissue Location||Strongly expressed in pancreas, kidney (adult and fetal), skeletal muscle, melanocytes and keratinocytes Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal). Isoform 2 represents 5-20 % of CTNS transcripts, with the exception of the testis that expresses both isoforms in equal proportions|
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This gene encodes a seven-transmembrane domain proteinthat functions to transport cystine out of lysosomes. Its activityis driven by the H+ electrochemical gradient of the lysosomalmembrane. Mutations in this gene cause cystinosis, a lysosomalstorage disorder. Alternative splicing results in multipletranscript variants.
Taranta, A., et al. Pediatr. Nephrol. 25(7):1263-1267(2010)Bellomo, F., et al. Free Radic. Biol. Med. 48(7):865-872(2010)Kumar, A., et al. J. Biosci. 35(1):21-25(2010)Aldahmesh, M.A., et al. Ophthalmic Genet. 30(4):185-189(2009)Macias-Vidal, J., et al. Clin. Genet. 76(5):486-489(2009)
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