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SSH1 Antibody(N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q8WYL5
Clone Names 100623242
Peptide ID 100623242
Additional Information
Gene ID 54434
Other Names Protein phosphatase Slingshot homolog 1, SSH-like protein 1, SSH-1L, hSSH-1L, SSH1, KIAA1298, SSH1L
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SSH1
Synonyms KIAA1298, SSH1L
Function Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein.
Cellular Location Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion Also localized to the cleavage furrow and the midbody during cytokinesis
Research Areas
Citations (0)

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The ADF (actin-depolymerizing factor)/cofilin family (seeMIM 601442) is composed of stimulus-responsive mediators of actindynamics. ADF/cofilin proteins are inactivated by kinases such asLIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears toplay a role in actin dynamics by reactivating ADF/cofilin proteinsin vivo (Niwa et al., 2002 [PubMed 11832213]).


Song, S.Y., et al. APMIS 118(5):389-393(2010)Peterburs, P., et al. Cancer Res. 69(14):5634-5638(2009)Kligys, K., et al. Biochem. Biophys. Res. Commun. 383(4):450-454(2009)Kim, J.S., et al. Mol. Biol. Cell 20(11):2650-2660(2009)Huang, T.Y., et al. Dev. Cell 15(5):691-703(2008)

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$ 80.00
Cat# BP19412a
Availability: In Stock
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