|Other Names||Paired mesoderm homeobox protein 1, Homeobox protein PHOX1, Paired-related homeobox protein 1, PRX-1, PRRX1, PMX1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (By similarity).|
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The DNA-associated protein encoded by this gene is amember of the paired family of homeobox proteins localized to thenucleus. The protein functions as a transcription co-activator,enhancing the DNA-binding activity of serum response factor, aprotein required for the induction of genes by growth anddifferentiation factors. The protein regulates muscle creatinekinase, indicating a role in the establishment of diversemesodermal muscle types. Alternative splicing yields two isoformsthat differ in abundance and expression patterns. [provided byRefSeq].
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Hirose, K., et al. Oncogene 27(46):6056-6067(2008)Vieira, A.R., et al. Genet. Med. 10(9):668-674(2008)Jiang, F., et al. Exp. Biol. Med. (Maywood) 233(3):286-296(2008)Kim, Y.J., et al. Cancer Res. 67(2):546-554(2007)
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