|Other Names||Ephrin type-B receptor 6, MEP, Tyrosine-protein kinase-defective receptor EPH-6, Ephb6, Cekl|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Secreted.|
|Tissue Location||High level in thymus, and brain. Very low levels of expression in kidney, lung, liver, bone marrow, skeletal muscle, spleen from 2 week old and adult mice, heart, testes and embryonic stem cells.|
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Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity).
Islam, S., et al. Dig. Dis. Sci. 55(9):2478-2488(2010)Lieben, L., et al. Bone 47(2):301-308(2010)Mordan-McCombs, S., et al. J. Steroid Biochem. Mol. Biol. 121 (1-2), 368-371 (2010) :Zirzow, S., et al. Dev. Biol. 336(2):145-155(2009)Chou, S.J., et al. Nat. Neurosci. 12(11):1381-1389(2009)
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