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ZHX1 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UKY1 |
|---|---|
| Clone Names | 100712134 |
| Gene ID | 11244 |
|---|---|
| Other Names | Zinc fingers and homeoboxes protein 1, ZHX1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZHX1 |
|---|---|
| Function | Acts as a transcriptional repressor. Increases DNMT3B- mediated repressive transcriptional activity when DNMT3B is tethered to DNA. May link molecule between DNMT3B and other co-repressor proteins. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12237128, ECO:0000269|PubMed:17056598} Note=Colocalized in the nucleus with DNMT3B |
| Tissue Location | Ubiquitously expressed. Expressed in podocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The members of the zinc fingers and homeoboxes gene familyare nuclear homodimeric transcriptional repressors that interactwith the A subunit of nuclear factor-Y (NF-YA) and contain twoC2H2-type zinc fingers and five homeobox DNA-binding domains. Thisgene encodes member 1 of this gene family. In addition to forminghomodimers, this protein heterodimerizes with members 2 and 3 ofthe zinc fingers and homeoboxes family. Alternative splicingresults in multiple transcript variants encoding the same protein.
References
Wienk, H., et al. Biochemistry 48(21):4431-4439(2009)Rikova, K., et al. Cell 131(6):1190-1203(2007)Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Kim, S.H., et al. Biochem. Biophys. Res. Commun. 355(2):318-323(2007)Liu, G., et al. J. Biol. Chem. 281(51):39681-39692(2006)
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