|Other Names||Plexin domain-containing protein 1, Tumor endothelial marker 3, Tumor endothelial marker 7, PLXDC1, TEM3, TEM7|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a critical role in endothelial cell capillary morphogenesis.|
|Cellular Location||Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells Isoform 3: Secreted.|
|Tissue Location||Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy.|
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Plays a critical role in endothelial cell capillary morphogenesis.
Rose, J. Phd, et al. Mol. Med. (2010) In press :Halder, C., et al. Anticancer Res. 29(11):4317-4322(2009)Yamaji, Y., et al. Invest. Ophthalmol. Vis. Sci. 49(7):3151-3157(2008)Fuchs, B., et al. Gene 399(2):137-143(2007)Nanda, A., et al. Cancer Res. 64(23):8507-8511(2004)
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