Mouse Dok1 Antibody (C-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Clone Names | 110919114 |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
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Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3 (By similarity).
References
Titz, B., et al. Oncogene 29(44):5895-5910(2010)Mashima, R., et al. Lab. Invest. 90(9):1357-1364(2010)Berger, A.H., et al. Nat. Genet. 42(3):216-223(2010)Warner, N., et al. FEBS J. 275(10):2561-2573(2008)Hosooka, T., et al. Nat. Med. 14(2):188-193(2008)
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