|Other Names||Regulator of G-protein signaling 13, RGS13, RGS13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)- alpha (By similarity).|
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The protein encoded by this gene is a member of theregulator of G protein signaling (RGS) family. RGS family membersshare similarity with S. cerevisiae SST2 and C. elegans egl-10proteins, which contain a characteristic conserved RGS domain. RGSproteins accelerate GTPase activity of G protein alpha-subunits,thereby driving G protein into their inactive GDP-bound form, thusnegatively regulating G protein signaling. RGS proteins have beenimplicated in the fine tuning of a variety of cellular events inresponse to G protein-coupled receptor activation. The biologicalfunction of this gene, however, is unknown. Two transcript variantsencoding the same isoform exist.
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Bansal, G., et al. J. Immunol. 181(11):7882-7890(2008)Han, J.I., et al. J. Leukoc. Biol. 79(6):1357-1368(2006)Islam, T.C., et al. Leukemia 17(9):1880-1890(2003)
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