RGS13 Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14921 |
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Clone Names | 100603169 |
Gene ID | 6003 |
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Other Names | Regulator of G-protein signaling 13, RGS13, RGS13 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RGS13 |
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Function | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to both G(i)-alpha and G(q)-alpha (By similarity). |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of theregulator of G protein signaling (RGS) family. RGS family membersshare similarity with S. cerevisiae SST2 and C. elegans egl-10proteins, which contain a characteristic conserved RGS domain. RGSproteins accelerate GTPase activity of G protein alpha-subunits,thereby driving G protein into their inactive GDP-bound form, thusnegatively regulating G protein signaling. RGS proteins have beenimplicated in the fine tuning of a variety of cellular events inresponse to G protein-coupled receptor activation. The biologicalfunction of this gene, however, is unknown. Two transcript variantsencoding the same isoform exist.
References
Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Bansal, G., et al. J. Immunol. 181(11):7882-7890(2008)Han, J.I., et al. J. Leukoc. Biol. 79(6):1357-1368(2006)Islam, T.C., et al. Leukemia 17(9):1880-1890(2003)
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