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GUCA1B Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UMX6 |
|---|---|
| Clone Names | 100617192 |
| Gene ID | 2979 |
|---|---|
| Other Names | Guanylyl cyclase-activating protein 2, GCAP 2, Guanylate cyclase activator 1B, GUCA1B, GCAP2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | GUCA1B |
|---|---|
| Synonyms | GCAP2 |
| Function | Stimulates two retinal guanylyl cyclases (GCs) GUCY2D and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2D and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (By similarity). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P51177}; Lipid-anchor {ECO:0000250|UniProtKB:P51177}. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment Note=Subcellular location is not affected by light or dark conditions {ECO:0000250|UniProtKB:Q8VBV8} |
| Tissue Location | In the retina, it is expressed in cone and rod photoreceptor cells. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a calcium-bindingprotein that activates photoreceptor guanylate cyclases. This genemay have arisen due to a gene duplication event since there is ahighly similar gene clustered with it on chromosome 6. Mutations inthis gene can cause a form of retinitis pigmentosa. [provided byRefSeq].
References
Sato, M., et al. Graefes Arch. Clin. Exp. Ophthalmol. 243(3):235-242(2005)Nishiguchi, K.M., et al. Invest. Ophthalmol. Vis. Sci. 45(11):3863-3870(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :Zhang, Q.J., et al. Yi Chuan 24(1):19-21(2002)
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