|Other Names||Guanylyl cyclase-activating protein 2, GCAP 2, Guanylate cyclase activator 1B, GUCA1B, GCAP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low, and GC1 and GC2 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.|
|Cellular Location||Cell membrane. Note=Membranes of outer segment|
|Tissue Location||Retina. Cones and rod.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a calcium-bindingprotein that activates photoreceptor guanylate cyclases. This genemay have arisen due to a gene duplication event since there is ahighly similar gene clustered with it on chromosome 6. Mutations inthis gene can cause a form of retinitis pigmentosa. [provided byRefSeq].
Sato, M., et al. Graefes Arch. Clin. Exp. Ophthalmol. 243(3):235-242(2005)Nishiguchi, K.M., et al. Invest. Ophthalmol. Vis. Sci. 45(11):3863-3870(2004)Mungall, A.J., et al. Nature 425(6960):805-811(2003)Wistow, G., et al. Mol. Vis. 8, 196-204 (2002) :Zhang, Q.J., et al. Yi Chuan 24(1):19-21(2002)
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