|Other Names||ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RecQ4, RTS, RecQ protein-like 4, RECQL4, RECQ4|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-dependent ATPase. May modulate chromosome segregation.|
|Cellular Location||Cytoplasm. Nucleus|
|Tissue Location||Ubiquitously expressed, with highest levels in thymus and testis.|
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The protein encoded by this gene is a DNA helicase thatbelongs to the RecQ helicase family. DNA helicases unwinddouble-stranded DNA into single-stranded DNAs and may modulatechromosome segregation. This gene is predominantly expressed inthymus and testis. Mutations in this gene are associated withRothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [providedby RefSeq].
Rossi, M.L., et al. DNA Repair (Amst.) 9(7):796-804(2010)Singh, D.K., et al. Aging Cell 9(3):358-371(2010)Thangavel, S., et al. Mol. Cell. Biol. 30(6):1382-1396(2010)Xu, X., et al. EMBO J. 28(19):3005-3014(2009)Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)
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