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RECQL4 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | O94761 |
|---|---|
| Clone Names | 100623007 |
| Gene ID | 9401 |
|---|---|
| Other Names | ATP-dependent DNA helicase Q4, DNA helicase, RecQ-like type 4, RecQ4, RTS, RecQ protein-like 4, RECQL4, RECQ4 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | RECQL4 |
|---|---|
| Synonyms | RECQ4 {ECO:0000303|PubMed:9878247} |
| Function | An ATP-dependent DNA helicase which unwinds dsDNA with a 3'- overhang in a 3'-5' direction (PubMed:28653661). Does not unwind more than 18 bp of dsDNA (PubMed:28653661). May modulate chromosome segregation. The N-terminal domain (residues 1-54) binds DNA Y-shaped DNA better than ss- or dsDNA (PubMed:22730300). The core helicase domain binds ssDNA (PubMed:28653661, PubMed:22730300). |
| Cellular Location | Cytoplasm. Nucleus |
| Tissue Location | Ubiquitously expressed, with highest levels in thymus and testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a DNA helicase thatbelongs to the RecQ helicase family. DNA helicases unwinddouble-stranded DNA into single-stranded DNAs and may modulatechromosome segregation. This gene is predominantly expressed inthymus and testis. Mutations in this gene are associated withRothmund-Thomson, RAPADILINO and Baller-Gerold syndromes. [providedby RefSeq].
References
Rossi, M.L., et al. DNA Repair (Amst.) 9(7):796-804(2010)Singh, D.K., et al. Aging Cell 9(3):358-371(2010)Thangavel, S., et al. Mol. Cell. Biol. 30(6):1382-1396(2010)Xu, X., et al. EMBO J. 28(19):3005-3014(2009)Im, J.S., et al. Proc. Natl. Acad. Sci. U.S.A. 106(37):15628-15632(2009)
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