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SPIB Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q01892 |
|---|---|
| Clone Names | 100712156 |
| Gene ID | 6689 |
|---|---|
| Other Names | Transcription factor Spi-B, SPIB |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SPIB |
|---|---|
| Function | Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. May be required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. |
| Cellular Location | [Isoform 1]: Nucleus |
| Tissue Location | Expressed in plasmacytoid dendritic cells (pDCs) and B-cells, not expressed in T-cells or granulocytes. May also be enriched in stem cell populations of the liver |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
SPI1 (MIM 165170) and SPIB are members of a subfamily ofETS (see ETS1; MIM 164720) transcription factors. ETS proteinsshare a conserved ETS domain that mediates specific DNA binding.SPIB and SPI1 bind to a purine-rich sequence, the PU box(5-prime-GAGGAA-3-prime).
References
Liu, X., et al. Nat. Genet. 42(8):658-660(2010)Schmidlin, H., et al. Blood 112(5):1804-1812(2008)Nagasawa, M., et al. Eur. J. Immunol. 38(9):2389-2400(2008)Dontje, W., et al. Blood 107(6):2446-2452(2006)Geng, C.D., et al. J. Biol. Chem. 280(52):43264-43271(2005)
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