|Other Names||Beta-galactoside alpha-2, 6-sialyltransferase 2, Alpha 2, 6-ST 2, CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 6-sialyltransferase 2, ST6Gal II, ST6GalII, hST6Gal II, Sialyltransferase 2, ST6GAL2, KIAA1877, SIAT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transfers sialic acid from the donor of substrate CMP- sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.|
|Cellular Location||Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein|
|Tissue Location||Weakly expressed in some tissues, such as small intestine, colon and fetal brain|
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Provided below are standard protocols that you may find useful for product applications.
Sialyltransferases, such as ST6GAL2 (EC 22.214.171.124), aretype II transmembrane proteins that catalyze the transfer of sialicacid from CMP-sialic acid to an acceptor carbohydrate, usually tothe terminal ends of carbohydrate chains.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Ikeda, M., et al. Biol. Psychiatry 67(3):263-269(2010)Lehoux, S., et al. Glycoconj. J. 27(1):99-114(2010)Trynka, G., et al. Gut 58(8):1078-1083(2009)Krzewinski-Recchi, M.A., et al. Eur. J. Biochem. 270(5):950-961(2003)
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