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ST6GALNAC5 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9BVH7 |
|---|---|
| Clone Names | 110726234 |
| Gene ID | 81849 |
|---|---|
| Other Names | Alpha-N-acetylgalactosaminide alpha-2, 6-sialyltransferase 5, 2499-, GD1 alpha synthase, GalNAc alpha-2, 6-sialyltransferase V, ST6GalNAc V, ST6GalNAcV, Sialyltransferase 7E, SIAT7-E, ST6GALNAC5, SIAT7E |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ST6GALNAC5 |
|---|---|
| Synonyms | SIAT7E |
| Function | Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N- acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl- (1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)- beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
ST6GALNAC5 belongs to a family of sialyltransferases thatmodify proteins and ceramides on the cell surface to altercell-cell or cell-extracellular matrix interactions (Tsuchida etal., 2003 [PubMed 12668675]).
References
Rose, J. Phd, et al. Mol. Med. (2010) In press :Harduin-Lepers, A., et al. Glycobiology 15(8):805-817(2005)Tsuchida, A., et al. J. Biol. Chem. 278(25):22787-22794(2003)Ikehara, Y., et al. FEBS Lett. 463 (1-2), 92-96 (1999) :Okajima, T., et al. J. Biol. Chem. 274(43):30557-30562(1999)
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