GPR52 Antibody(C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9Y2T5 |
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Clone Names | 110811089 |
Gene ID | 9293 |
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Other Names | Probable G-protein coupled receptor 52, GPR52 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | GPR52 {ECO:0000303|PubMed:9931487, ECO:0000312|HGNC:HGNC:4508} |
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Function | Gs-coupled receptor activated by antipsychotics reserpine leading to an increase in intracellular cAMP and its internalization (PubMed:24587241). May play a role in locomotor activity through modulation of dopamine, NMDA and ADORA2A-induced locomotor activity. These behavioral changes are accompanied by modulation of the dopamine receptor signaling pathway in striatum (PubMed:24587241). Modulates HTT level via cAMP-dependent but PKA independent mechanisms throught activation of RAB39B that translocates HTT to the endoplasmic reticulum, thus avoiding proteasome degradation (PubMed:25738228). |
Cellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Location | Expressed in brain, especially in striatum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Members of the G protein-coupled receptor (GPR) familyplay important roles in signal transduction from the externalenvironment to the inside of the cell.
References
Sawzdargo, M., et al. Brain Res. Mol. Brain Res. 64(2):193-198(1999)
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