|Other Names||F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5, FBXW5, FBW5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway.|
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This gene encodes a member of the F-box protein family,members of which are characterized by an approximately 40 aminoacid motif, the F-box. The F-box proteins constitute one of thefour subunits of ubiquitin protein ligase complex called SCFs(SKP1-cullin-F-box), which function in phosphorylation-dependentubiquitination. The F-box proteins are divided into three classes:Fbws containing WD-40 domains, Fbls containing leucine-richrepeats, and Fbxs containing either different protein-proteininteraction modules or no recognizable motifs. The protein encodedby this gene contains WD-40 domains, in addition to an F-box motif,so it belongs to the Fbw class. Alternatively spliced transcriptvariants encoding distinct isoforms have been identified for thisgene, however, they were found to be nonsense-mediated mRNA decay(NMD) candidates, hence not represented.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Minoda, Y., et al. Biochem. Biophys. Res. Commun. 381(3):412-417(2009)Hu, J., et al. Genes Dev. 22(7):866-871(2008)Wan, D., et al. Proc. Natl. Acad. Sci. U.S.A. 101(44):15724-15729(2004)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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