|Other Names||RNA 3'-terminal phosphate cyclase-like protein, RCL1, RNAC, RPC2, RPCL1, RTC2|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1949a was selected from the N-term region of human RCL1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||RNAC, RPC2, RPCL1, RTC2|
|Function||Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).|
|Cellular Location||Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
RCL1, which does not have cyclase activity, plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.
Billy, E., et al., EMBO J. 19(9):2115-2126 (2000). Genschik P., et al., EMBO J. 16(10):2955-67 (1997).
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