|Other Names||Volume-regulated anion channel subunit LRRC8A, Leucine-rich repeat-containing protein 8A, Swelling protein 1, LRRC8A, KIAA1437, LRRC8, SWELL1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||KIAA1437, LRRC8, SWELL1|
|Function||Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. It is unclear whether LRRC8A constitutes a pore-forming subunit or whether it is closely associated with the pore and mediates channel properties such as ion selectivity. Involved in B-cell development: required for the pro-B cell to pre-B cell transition. Also required for T-cell development.|
|Cellular Location||Cell membrane; Multi- pass membrane protein|
|Tissue Location||Expressed in brain, kidney, ovary, lung, liver, heart, and fetal brain and liver. Found at high levels in bone marrow; lower levels are detected in peripheral blood cells Expressed on T-cells as well as on B-lineage cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein belonging to the leucine-richrepeat family of proteins, which are involved in diverse biologicalprocesses, including cell adhesion, cellular trafficking, andhormone-receptor interactions. This family member is a putativefour-pass transmembrane protein that plays a role in B celldevelopment. Defects in this gene cause autosomal dominantnon-Bruton type agammaglobulinemia, an immunodeficiency diseaseresulting from defects in B cell maturation. Multiple alternativelyspliced transcript variants, which encode the same protein, havebeen identified for this gene.
Olsen, J.V., et al. Cell 127(3):635-648(2006)Smits, G., et al. Mol. Immunol. 41(5):561-562(2004)Kubota, K., et al. FEBS Lett. 564 (1-2), 147-152 (2004) :Sawada, A., et al. J. Clin. Invest. 112(11):1707-1713(2003)Conley, M.E. J. Clin. Invest. 112(11):1636-1638(2003)
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