|Other Names||Transcription factor 7, TCF-7, T-cell-specific transcription factor 1, T-cell factor 1, TCF-1, TCF7, TCF1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1951a was selected from the N-term region of human TCF7. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T- lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.|
|Tissue Location||Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium|
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Provided below are standard protocols that you may find useful for product applications.
The T cell specific transcription factor TCF7 activates genes involved in immune regulation and thymocyte differentiation, and is a candidate locus for genetic susceptibility to type 1 diabetes.
Smit, L., et al., J. Biol. Chem. 279(17):17232-17240 (2004).Ioannidis, V., et al., J. Immunol. 171(2):769-775 (2003).Noble, J.A., et al., Diabetes 52(6):1579-1582 (2003).Batlle, E., et al., Cell 111(2):251-263 (2002).van de Wetering, M., et al., J. Biol. Chem. 267(12):8530-8536 (1992).
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