|Other Names||Gamma-aminobutyric acid receptor subunit rho-1, GABA(A) receptor subunit rho-1, GABA(C) receptor, GABRR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
|Tissue Location||Highly expressed in the retina and in a lesser extent in brain, lung and thymus|
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Provided below are standard protocols that you may find useful for product applications.
GABA is the major inhibitory neurotransmitter in themammalian brain where it acts at GABA receptors, which areligand-gated chloride channels. GABRR1 is a member of the rhosubunit family.
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :Green, E.K., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. (2010) In press :Reyes-Ruiz, J.M., et al. Biochim. Biophys. Acta 1798(5):1002-1007(2010)Xuei, X., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 418-427 (2010) :Kang, J.Q., et al. Trends Mol Med 15(9):430-438(2009)
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