EPS8L2 Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q9H6S3 |
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Clone Names | 100603135 |
Gene ID | 64787 |
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Other Names | Epidermal growth factor receptor kinase substrate 8-like protein 2, EPS8-like protein 2, Epidermal growth factor receptor pathway substrate 8-related protein 2, EPS8-related protein 2, EPS8L2, EPS8R2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | EPS8L2 |
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Synonyms | EPS8R2 |
Function | Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity). |
Cellular Location | Cytoplasm. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q99K30}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells {ECO:0000250|UniProtKB:Q99K30} |
Tissue Location | Detected in fibroblasts and placenta. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the EPS8 gene family. Theencoded protein, like other members of the family, is thought tolink growth factor stimulation to actin organization, generatingfunctional redundancy in the pathways that regulate actincytoskeletal remodeling.
References
Kim, J.E., et al. J. Proteome Res. 4(4):1339-1346(2005)Offenhauser, N., et al. Mol. Biol. Cell 15(1):91-98(2004)Tocchetti, A., et al. Genomics 81(2):234-244(2003)
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