|Other Names||TNF receptor-associated factor 6, 632-, E3 ubiquitin-protein ligase TRAF6, Interleukin-1 signal transducer, RING finger protein 85, TRAF6, RNF85|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production.|
|Cellular Location||Cytoplasm. Cytoplasm, cell cortex. Nucleus. Lipid droplet Note=Found in the nuclei of some aggressive B-cell lymphoma cell lines as well as in the nuclei of both resting and activated T- and B-lymphocytes. Found in punctate nuclear body protein complexes. Ubiquitination may occur in the cytoplasm and sumoylation in the nucleus. RSAD2/viperin recruits it to the lipid droplet (By similarity).|
|Tissue Location||Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas|
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The protein encoded by this gene is a member of the TNFreceptor associated factor (TRAF) protein family. TRAF proteins areassociated with, and mediate signal transduction from members ofthe TNF receptor superfamily. This protein mediates the signalingnot only from the members of the TNF receptor superfamily, but alsofrom the members of the Toll/IL-1 family. Signals from receptorssuch as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediatedby this protein. This protein also interacts with various proteinkinases including IRAK1/IRAK, SRC and PKCzeta, which provides alink between distinct signaling pathways. This protein functions asa signal transducer in the NF-kappaB pathway that activates IkappaBkinase (IKK) in response to proinflammatory cytokines. Theinteraction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A,which are ubiquitin conjugating enzymes catalyzing the formation ofpolyubiquitin chains, has been found to be required for IKKactivation by this protein. Two alternatively spliced transcriptvariants encoding identical proteins have been reported. [providedby RefSeq].
Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Hinz, M., et al. Mol. Cell 40(1):63-74(2010)Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Stachon, P., et al. PLoS ONE 5 (7), E11589 (2010) :
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