RAET1E Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8TD07 |
---|---|
Clone Names | 100405179 |
Gene ID | 135250 |
---|---|
Other Names | NKG2D ligand 4, N2DL-4, NKG2DL4, Lymphocyte effector toxicity activation ligand, RAE-1-like transcript 4, RL-4, Retinoic acid early transcript 1E, RAET1E, LETAL, N2DL4, ULBP4 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RAET1E {ECO:0000303|PubMed:11827464, ECO:0000312|HGNC:HGNC:16793} |
---|---|
Function | Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. |
Cellular Location | Membrane; Single- pass type I membrane protein |
Tissue Location | Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Members of the RAET1 family, such as RAET1E, are majorhistocompatibility complex (MHC) class I-related genes locatedwithin a 180-kb cluster on chromosome 6q24.2-q25.3. RAET1 proteinscontain MHC class I-like alpha-1 and alpha-2 domains. RAET1E andRAET1G (MIM 609244) differ from the other RAET1 proteins (e.g.,RAET1I, or ULBP1; MIM 605697) in that they have type Imembrane-spanning sequences at their C termini rather thanglycosylphosphatidylinositol anchor sequences. RAET1E is a ligandfor NKG2D (KLRK1; MIM 611817), which is expressed on the surface ofseveral types of immune cells and is involved in innate andadaptive immune responses (summary by Radosavljevic et al. (2002)[PubMed 11827464] and Cao et al. (2007) [PubMed17470428]).
References
McGilvray, R.W., et al. Int. J. Cancer 127(6):1412-1420(2010)Antoun, A., et al. Hum. Immunol. 71(6):610-620(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Romphruk, A.V., et al. Immunogenetics 61(9):611-617(2009)Kong, Y., et al. Blood 114(2):310-317(2009)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.