|Other Names||Potassium voltage-gated channel subfamily B member 2, Voltage-gated potassium channel subunit Kv22, KCNB2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. Four sequence-relatedpotassium channel genes - shaker, shaw, shab, and shal - have beenidentified in Drosophila, and each has been shown to have humanhomolog(s). This gene encodes a member of the potassium channel,voltage-gated, shab-related subfamily. This member is a delayedrectifier potassium channel. The gene is expressed ingastrointestinal smooth muscle cells.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Cirulli, E.T., et al. Eur. J. Hum. Genet. 18(7):815-820(2010)Baranzini, S.E., et al. Hum. Mol. Genet. 18(4):767-778(2009)Nyholt, D.R., et al. Hum. Mol. Genet. 17(21):3318-3331(2008)Wu, C., et al. Proteomics 7(11):1775-1785(2007)
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