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VAX2 Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q9UIW0 |
|---|---|
| Clone Names | 100617011 |
| Gene ID | 25806 |
|---|---|
| Other Names | Ventral anterior homeobox 2, VAX2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | VAX2 |
|---|---|
| Function | Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina. |
| Cellular Location | Nucleus. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a homeobox protein and is almostexclusively expressed in the ventral portion of the retina duringdevelopment. In mouse studies, this gene was found to be requiredfor the correct formation of the optic fissure and other aspects ofretinal development.
References
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Holland, P.W., et al. BMC Biol. 5, 47 (2007) :Beaty, T.H., et al. Hum. Genet. 120(4):501-518(2006)Barbieri, A.M., et al. Proc. Natl. Acad. Sci. U.S.A. 96(19):10729-10734(1999)
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