|Other Names||Ventral anterior homeobox 2, VAX2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.|
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This gene encodes a homeobox protein and is almostexclusively expressed in the ventral portion of the retina duringdevelopment. In mouse studies, this gene was found to be requiredfor the correct formation of the optic fissure and other aspects ofretinal development.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Holland, P.W., et al. BMC Biol. 5, 47 (2007) :Beaty, T.H., et al. Hum. Genet. 120(4):501-518(2006)Barbieri, A.M., et al. Proc. Natl. Acad. Sci. U.S.A. 96(19):10729-10734(1999)
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