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RPC5 Antibody (N-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession Q9NVU0
Clone Names 50908359
Peptide ID 50908359
Additional Information
Gene ID 101060521;55718
Other Names DNA-directed RNA polymerase III subunit RPC5, RNA polymerase III subunit C5, DNA-directed RNA polymerase III 80 kDa polypeptide, POLR3E, KIAA1452
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1956a was selected from the N-term region of human RPC5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms KIAA1452
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Cellular Location Nucleus.
Research Areas
Citations (0)

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RNA polymerase III synthesizes RNA components of the protein synthesis, pre-mRNA splicing, and tRNA processing apparatuses. The holoenzyme consists of about 15 different subunits. The RPC5 subunit is essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters.


Hu, P., et al., Mol. Cell. Biol. 22(22):8044-8055 (2002).Jang, K.L., et al., J. Acquir. Immune Defic. Syndr. 5(11):1142-1147 (1992).

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$ 80.00
Cat# BP1956a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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