|Other Names||Potassium channel subfamily K member 6, Inward rectifying potassium channel protein TWIK-2, TWIK-originated similarity sequence, KCNK6, TOSS, TWIK2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical K(+) conditions.|
|Cellular Location||Membrane; Multi-pass membrane protein|
|Tissue Location||Widespread expression, detected in all tissues tested except for skeletal muscle. Strongest expression in placenta, pancreas, heart, colon and spleen, lower levels detected in peripheral blood leukocytes, lung, liver, kidney and thymus Lowest expression detected in brain|
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This gene encodes one of the members of the superfamily ofpotassium channel proteins containing two pore-forming P domains.This channel protein, considered an open rectifier, is widelyexpressed. It is stimulated by arachidonic acid, and inhibited byinternal acidification and volatile anaesthetics. [provided byRefSeq].
Sebastiani, P., et al. Am. J. Hematol. 85(1):29-35(2010)Gierten, J., et al. Br. J. Pharmacol. 154(8):1680-1690(2008)Goldstein, S.A., et al. Pharmacol. Rev. 57(4):527-540(2005)Mhatre, A.N., et al. J. Neurosci. Res. 75(1):25-31(2004)Goldstein, S.A., et al. Nat. Rev. Neurosci. 2(3):175-184(2001)
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