ERBB2 Antibody (Center T701) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Clone Names | 111026212 |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
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Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the epidermal growth factor(EGF) receptor family of receptor tyrosine kinases. This proteinhas no ligand binding domain of its own and therefore cannot bindgrowth factors. However, it does bind tightly to other ligand-boundEGF receptor family members to form a heterodimer, stabilizingligand binding and enhancing kinase-mediated activation ofdownstream signalling pathways, such as those involvingmitogen-activated protein kinase and phosphatidylinositol-3 kinase.Allelic variations at amino acid positions 654 and 655 of isoform a(positions 624 and 625 of isoform b) have been reported, with themost common allele, Ile654/Ile655, shown here. Amplification and/oroverexpression of this gene has been reported in numerous cancers,including breast and ovarian tumors. Alternative splicing resultsin several additional transcript variants, some encoding differentisoforms and others that have not been fully characterized.
References
Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)Zaoui, K., et al. Proc. Natl. Acad. Sci. U.S.A. 107(43):18517-18522(2010)Oliveras, G., et al. Ann. N. Y. Acad. Sci. 1210, 86-92 (2010) :Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010)Stackievicz, R., et al. Isr. Med. Assoc. J. 12(5):290-295(2010)
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