|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
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This gene encodes a transcriptional regulator with bimodalDNA-binding specificity, which binds to methylated CGCG and also tothe non-methylated consensus KAISO-binding site TCCTGCNA. Theprotein contains an N-terminal POZ/BTB domain and 3 C-terminal zincfinger motifs. It recruits the N-CoR repressor complex to promotehistone deacetylation and the formation of repressive chromatinstructures in target gene promoters. It may contribute to therepression of target genes of the Wnt signaling pathway, and mayalso activate transcription of a subset of target genes by therecruitment of catenin delta-2 (CTNND2). Its interaction withcatenin delta-1 (CTNND1) inhibits binding to both methylated andnon-methylated DNA. It also interacts directly with the nuclearimport receptor Importin-α2 (also known as karyopherin alpha2or RAG cohort 1), which may mediate nuclear import of this protein.Alternatively spliced transcript variants encoding the same proteinhave been identified.
Zhang, J., et al. Microvasc. Res. 80(2):233-239(2010)Zhigalova, N.A., et al. Mol. Biol. (Mosk.) 44(2):263-274(2010)Dai, S.D., et al. Lung Cancer 67(2):205-215(2010)Soubry, A., et al. PLoS ONE 5 (2), E9203 (2010) :Dai, S.D., et al. BMC Cancer 9, 178 (2009) :
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