|Other Names||TIMELESS-interacting protein, TIPIN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.|
|Cellular Location||Cytoplasm. Nucleus.|
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Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.
Kemp, M.G., et al. J. Biol. Chem. 285(22):16562-16571(2010)Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :Unsal-Kacmaz, K., et al. Mol. Cell. Biol. 27(8):3131-3142(2007)Gotter, A.L., et al. J. Mol. Biol. 366(1):36-52(2007)
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