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TIPIN Antibody(N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9BVW5
Clone Names 110726250
Peptide ID 110726250
Additional Information
Gene ID 54962
Other Names TIMELESS-interacting protein, TIPIN
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TIPIN
Function Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress.
Cellular Location Cytoplasm. Nucleus.
Research Areas
Citations (0)

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Background

Required for normal progression of S-phase. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light.

References

Kemp, M.G., et al. J. Biol. Chem. 285(22):16562-16571(2010)Leman, A.R., et al. J. Cell. Sci. 123 (PT 5), 660-670 (2010) :Utge, S.J., et al. PLoS ONE 5 (2), E9259 (2010) :Unsal-Kacmaz, K., et al. Mol. Cell. Biol. 27(8):3131-3142(2007)Gotter, A.L., et al. J. Mol. Biol. 366(1):36-52(2007)

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$ 80.00
Cat# BP19596a
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