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FADD Antibody(Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13158
Clone Names 100409019
Peptide ID 100409019
Additional Information
Gene ID 8772
Other Names FAS-associated death domain protein, FAS-associating death domain-containing protein, Growth-inhibiting gene 3 protein, Mediator of receptor induced toxicity, Protein FADD, FADD, MORT1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms MORT1
Function Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Location Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes
Research Areas
Citations (0)

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The protein encoded by this gene is an adaptor moleculethat interacts with various cell surface receptors and mediatescell apoptotic signals. Through its C-terminal death domain, thisprotein can be recruited by TNFRSF6/Fas-receptor, tumor necrosisfactor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus itparticipates in the death signaling initiated by these receptors.Interaction of this protein with the receptors unmasks theN-terminal effector domain of this protein, which allows it torecruit caspase-8, and thereby activate the cysteine proteasecascade. Knockout studies in mice also suggest the importance ofthis protein in early T cell development.


Hindryckx, P., et al. J. Immunol. 185(10):6306-6316(2010)Silva, L.K., et al. Eur. J. Hum. Genet. 18(11):1221-1227(2010)Papoff, G., et al. Biochim. Biophys. Acta 1803(8):898-911(2010)Li, P., et al. J. Biol. Chem. 285(29):22713-22722(2010)Ko, C.L., et al. Chang Gung Med J 33(2):145-151(2010)

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$ 80.00
Cat# BP19607c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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