TXNRD3 Antibody(Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q86VQ6 |
---|---|
Clone Names | 100416186 |
Gene ID | 114112 |
---|---|
Other Names | Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2, TXNRD3 {ECO:0000312|EMBL:AAH500321} |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TXNRD3 {ECO:0000312|EMBL:AAH50032.1} |
---|---|
Function | Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity). |
Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum Note=Detected in cytoplasm and nucleus in late spermatids {ECO:0000250|UniProtKB:Q99MD6} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the family of pyridinenucleotide oxidoreductases. This protein catalyzes the reduction ofthioredoxin, and is implicated in the defense against oxidativestress. It contains a selenocysteine (Sec) residue (which isessential for catalytic activity), encoded by a UGA codon, at thepenultimate C-terminal position. The 3' UTR of Sec-containing geneshave a common stem-loop structure, the sec insertion sequence(SECIS), which is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.
References
Gerashchenko, M.V., et al. J. Biol. Chem. 285(7):4595-4602(2010)Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)Harris, S.E., et al. BMC Genet. 8, 43 (2007) :Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)Sun, Q.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(7):3673-3678(2001)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.