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TXNRD3 Antibody(Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q86VQ6
Clone Names 100416186
Additional Information
Gene ID 114112
Other Names Thioredoxin reductase 3, Thioredoxin and glutathione reductase, Thioredoxin reductase TR2, TXNRD3 {ECO:0000312|EMBL:AAH500321}
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TXNRD3 {ECO:0000312|EMBL:AAH50032.1}
Function Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components (By similarity).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q99MD6}. Nucleus {ECO:0000250|UniProtKB:Q99MD6}. Microsome {ECO:0000250|UniProtKB:Q99MD6}. Endoplasmic reticulum Note=Detected in cytoplasm and nucleus in late spermatids {ECO:0000250|UniProtKB:Q99MD6}
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the family of pyridinenucleotide oxidoreductases. This protein catalyzes the reduction ofthioredoxin, and is implicated in the defense against oxidativestress. It contains a selenocysteine (Sec) residue (which isessential for catalytic activity), encoded by a UGA codon, at thepenultimate C-terminal position. The 3' UTR of Sec-containing geneshave a common stem-loop structure, the sec insertion sequence(SECIS), which is necessary for the recognition of UGA as a Seccodon rather than as a stop signal. Alternatively splicedtranscript variants encoding different isoforms have been found forthis gene.

References

Gerashchenko, M.V., et al. J. Biol. Chem. 285(7):4595-4602(2010)Starr, J.M., et al. Mech. Ageing Dev. 129(12):745-751(2008)Harris, S.E., et al. BMC Genet. 8, 43 (2007) :Kryukov, G.V., et al. Science 300(5624):1439-1443(2003)Sun, Q.A., et al. Proc. Natl. Acad. Sci. U.S.A. 98(7):3673-3678(2001)

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$ 277.78
Cat# BP19608c
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