RNF182 Antibody(N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q8N6D2 |
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Clone Names | 100422131 |
Gene ID | 221687 |
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Other Names | E3 ubiquitin-protein ligase RNF182, 632-, RING finger protein 182, RNF182 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | RNF182 |
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Function | E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514). |
Cellular Location | Membrane; Multi-pass membrane protein. Cytoplasm |
Tissue Location | Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514). |
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Provided below are standard protocols that you may find useful for product applications.
Background
E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.
References
Liu, Q.Y., et al. Mol Neurodegener 3, 4 (2008) :
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