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RNF182 Antibody(N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q8N6D2
Clone Names 100422131
Additional Information
Gene ID 221687
Other Names E3 ubiquitin-protein ligase RNF182, 632-, RING finger protein 182, RNF182
Format Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name RNF182
Function E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway (PubMed:18298843). Also plays a role in the inhibition of TLR- triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA (PubMed:31432514).
Cellular Location Membrane; Multi-pass membrane protein. Cytoplasm
Tissue Location Up-regulated in neuronal cells subjected to cell death-inducing injuries, such as oxygen and glucose deprivation (at protein level). Could be up-regulated in Alzheimer disease brains (PubMed:18298843). Highly expressed in innate immune organs such as lymph nodes and spleen and in immune cells such as macrophages and dendritic cells (PubMed:31432514).
Research Areas
Citations (0)
citation

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Background

E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway.

References

Liu, Q.Y., et al. Mol Neurodegener 3, 4 (2008) :

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$ 277.78
Cat# BP19609a
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