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Dcr-1 Antibody (C-term) Blocking Peptide

Synthetic peptide

Product Information
Primary Accession P34529
Clone Names 6022602
Peptide ID 6022602
Additional Information
Gene ID 176138
Other Names Endoribonuclease dcr-1, 3126-, dcr-1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1961b was selected from the C-term region of human Dcr-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name dcr-1
Function Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing.
Research Areas
Citations (0)

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The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.


Duchaine TF, et al. 2006. Cell 124:343-354. Denli AM, et al. 2004. Nature 432:231-235. Tabara H, et al. 2002. Cell 109:861-871. Grishok A, et al. 2001. Cell 106:23-34. Knight SW, et al. 2001. Science 293:2269-2271.

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$ 80.00
Cat# BP1961b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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Ordering Information

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