|Other Names||Endoribonuclease dcr-1, 3126-, dcr-1|
|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1961c was selected from the Center region of human Dcr-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. Seems to process the precursor of the small temporal RNA let-7 which is involved in developmental timing.|
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Provided below are standard protocols that you may find useful for product applications.
The Dcr-1 gene encodes a bidentate ribonuclease that is homologous to E. coli RNAse III. Dcr-1 is required both for RNA interference and for synthesis of small developmental RNAs. Dcr-1 interacts in vivo with RDE-4, a double-stranded RNA (dsRNA) binding protein required for RNAi that interacts with trigger dsRNAs and may function to deliver dsRNAs to Dcr-1 for endonucleolytic processing.
Duchaine TF, et al. 2006. Cell 124:343-354.Denli AM, et al. 2004. Nature 432:231-235.Tabara H, et al. 2002. Cell 109:861-871.Grishok A, et al. 2001. Cell 106:23-34.Knight SW, et al. 2001. Science 293:2269-2271.
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