|Other Names||Cannabinoid receptor 1, CB-R, CB1, CANN6, CNR1, CNR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in cannabinoid-induced CNS effects. Acts by inhibiting adenylate cyclase. Could be a receptor for anandamide. Inhibits L-type Ca(2+) channel current. Isoform 2 and isoform 3 have altered ligand binding.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
|Tissue Location||Widely expressed.|
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This gene encodes one of two cannabinoid receptors. Thecannabinoids, principally delta-9-tetrahydrocannabinol andsynthetic analogs, are psychoactive ingredients of marijuana. Thecannabinoid receptors are members of the guanine-nucleotide-bindingprotein (G-protein) coupled receptor family, which inhibitadenylate cyclase activity in a dose-dependent, stereoselective andpertussis toxin-sensitive manner. The two receptors have been foundto be involved in the cannabinoid-induced CNS effects (includingalterations in mood and cognition) experienced by users ofmarijuana. Multiple transcript variants encoding two differentprotein isoforms have been described for this gene. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Van Laere, K., et al. J. Nucl. Med. 51(9):1413-1417(2010)Larrinaga, G., et al. Histol. Histopathol. 25(9):1133-1138(2010)Monteleone, P., et al. J Clin Psychopharmacol 30(4):441-445(2010)Thors, L., et al. PLoS ONE 5 (8), E12275 (2010) :
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