|Other Names||Opioid-binding protein/cell adhesion molecule, OBCAM, OPCML, Opioid-binding cell adhesion molecule, IgLON family member 1, OPCML, IGLON1, OBCAM|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Binds opioids in the presence of acidic lipids; probably involved in cell contact.|
|Cellular Location||Cell membrane; Lipid-anchor, GPI-anchor|
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This gene encodes a member of the IgLON subfamily in theimmunoglobulin protein superfamily. The encoded protein islocalized in the plasma membrane and may have an accessory role inopioid receptor function. This gene has an ortholog in rat andbovine. The opioid binding-cell adhesion molecule encoded by therat gene binds opioid alkaloids in the presence of acidic lipids,exhibits selectivity for mu ligands and acts as a GPI-anchoredprotein. Since the encoded protein is highly conserved in speciesduring evolution, it may have a fundamental role in mammaliansystems. Two transcript variants encoding different isoforms havebeen found for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Stolk, L., et al. Nat. Genet. (2009) In press :Cui, Y., et al. PLoS ONE 3 (8), E2990 (2008) :
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