Drh-1 Antibody (N-term) Blocking Peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | G5EDI8 |
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Other Accession | O44165 |
Clone Names | 50908376 |
Target/Specificity | The synthetic peptide sequence used to generate the antibody AP1962a was selected from the N-term region of human Drh-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay. |
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Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Human Drh-1 protein possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.The 21-nucleotide small temporal RNA (stRNA) let7 regulates developmental timing in C. elegans and probably in other bilateral animals. In Drosophila, a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let7 stRNA. Targeted disruption in cultured human cells of the mRNA encoding the enzyme Drh-1, which acts in the RNA interference pathway, leads to accumulation of the LET7 precursor. Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA processing enzyme Drh-1 to produce the active small RNA component that represses gene expression.
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