|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1962a was selected from the N-term region of human Drh-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Human Drh-1 protein possesses an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. DICER, also known as helicase-MOI, is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression.The 21-nucleotide small temporal RNA (stRNA) let7 regulates developmental timing in C. elegans and probably in other bilateral animals. In Drosophila, a developmentally regulated precursor RNA is cleaved by an RNA interference-like mechanism to produce mature let7 stRNA. Targeted disruption in cultured human cells of the mRNA encoding the enzyme Drh-1, which acts in the RNA interference pathway, leads to accumulation of the LET7 precursor. Thus, the RNA interference and stRNA pathways intersect. Both pathways require the RNA processing enzyme Drh-1 to produce the active small RNA component that represses gene expression.
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.