|Other Names||Fibroblast growth factor 8, FGF-8, Androgen-induced growth factor, AIGF, Heparin-binding growth factor 8, HBGF-8, Fgf8, Aigf|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells (By similarity). Cooperates with Wnt-1 in mouse mammary tumor virus- induced murine mammary tumorigenesis (PubMed:7884899).|
|Tissue Location||Absent in normal mammary glands and detected only in adult testis and ovary and in midgestational embryos|
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Stimulates growth of the cells in an autocrine manner. Mediates hormonal action on the growth of cancer cells. Cooperates with Wnt-1 in mouse mammary tumor virus-induced murine mammary tumorigenesis.
Yu, S., et al. Dev. Biol. 347(1):92-108(2010)Toyoda, R., et al. Development 137(20):3439-3448(2010)Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)Mao, J., et al. Development 137(18):3079-3088(2010)Mitsiadis, T.A., et al. Development 137(18):3025-3035(2010)
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