|Target/Specificity||The synthetic peptide sequence used to generate the antibody AP1963a was selected from the N-term region of human Gfl-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.|
|Format||The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Gfl-1 encodes a C. elegans ortholog of human Glioma-amplified sequence-41 (GAS41), found in increased copy number in low-grade glioma. Loss of GLF-1, which is predicted to associate with chromatin, results in potent suppression of the RNA interference (RNAi) mechanism. GLF-1 is also similar to the transcription factors (yeast and human) AF-9 and human ENL, and thus may represent a novel class of transcription factors.
Kim JK, et al. 2005. Science 308:1164-1167. Wang D, et al. 2005. Nature 436:593-597. Dudley NR, et al. 2002. PNAS USA 99:4191-4196
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