|Other Names||Guanine nucleotide-binding protein-like 3, Nucleolar GTP-binding protein 3, Nucleostemin, Gnl3, Ns|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be required to maintain the proliferative capacity of stem cells (By similarity). Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation.|
|Cellular Location||Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus|
|Tissue Location||Expressed in the adult bone marrow population that is enriched in hematopoietic stem cells|
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Provided below are standard protocols that you may find useful for product applications.
Gnl3 may be required to maintain the proliferative capacity of stem cells (By similarity).
Hirai, H., et al. Biochem. Biophys. Res. Commun. 391(1):299-304(2010)Tamase, A., et al. Proc. Natl. Acad. Sci. U.S.A. 106(40):17163-17168(2009)Nomura, J., et al. Stem Cells 27(5):1066-1076(2009)Ohmura, M., et al. Stem Cells 26(12):3237-3246(2008)Siddiqi, S., et al. Circ. Res. 103(1):89-97(2008)
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