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Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q92583 |
|---|---|
| Clone Names | 100408369 |
| Peptide ID | 100408369 |
| Gene ID | 6361 |
|---|---|
| Other Names | C-C motif chemokine 17, CC chemokine TARC, Small-inducible cytokine A17, Thymus and activation-regulated chemokine, CCL17, SCYA17, TARC |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCL17 |
|---|---|
| Synonyms | SCYA17, TARC |
| Function | Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4. |
| Cellular Location | Secreted. |
| Tissue Location | Expressed at high levels in thymus and at low levels in the lung, colon and small intestine |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is one of several Cys-Cys (CC) cytokine genesclustered on the q arm of chromosome 16. Cytokines are a family ofsecreted proteins involved in immunoregulatory and inflammatoryprocesses. The CC cytokines are proteins characterized by twoadjacent cysteines. The cytokine encoded by this gene displayschemotactic activity for T lymphocytes, but not monocytes orgranulocytes. The product of this gene binds to chemokine receptorsCCR4 and CCR8. This chemokine plays important roles in T celldevelopment in thymus as well as in trafficking and activation ofmature T cells.
References
Dallos, T., et al. Arthritis Rheum. 62(11):3496-3503(2010)Maruyama, T., et al. Dis. Esophagus 23(5):422-429(2010)Schuurhof, A., et al. Pediatr. Pulmonol. 45(6):608-613(2010)Davila, S., et al. Genes Immun. 11(3):232-238(2010)Narbutt, J., et al. Mediators Inflamm. 2009, 269541 (2009) :
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