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Rde-1 Antibody (Center) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession G5EEH0
Other Accession Q9XU82
Clone Names 6022403
Additional Information
Gene ID 179393
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1964c was selected from the Center region of human Rde-1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name G5EEH0
Research Areas
Citations (0)

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Background

Double-stranded (ds) RNA is a potent sequence-specific inhibitor of gene function. RNA interference (RNAi) is a cellular defense mechanism that uses double-stranded RNA (dsRNA) as a sequence-specific trigger to guide the degradation of homologous single-stranded RNAs. RNAi is a multistep process involving several proteins and at least one type of RNA intermediate, a population of small 21??5 nt RNAs (called siRNAs) that are initially derived from cleavage of the dsRNA trigger. Genetic studies have implicated several RNA interference-deficient (rde) family members in germline maintenance and development, and several simple loss of function mutants have been identified. Family members rde-1 and rde-4 are required for RNAi but are not essential for organismal viability. While rde-1 and rde-4 are distinct from other RNAi-deficient family members both both for their inability to mobilize transposons and lack of chromosome loss, each appears to have a distinct role in the interference mechanism. Evidence indicates that rde-4 is involved before or during production of siRNAs, whereas rde-1 acts after the siRNAs have been formed.

References

Tabara H, et al. Cell. 2002. 109(7):861-71. Parrish S,et al. RNA. 2001. 7(10):1397-402. Fagard M, et al. PNAS. 2000. 97(21):11650-4 Ketting RF, et al. Nature. 2000. 404(6775):296-8. Tabara H, et al. Cell. 1999. 99(2):123-32.

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$ 80.00
Cat# BP1964c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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