|Other Names||Histone H32, Histone H3/m, Histone H3/o, HIST2H3A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|
|Cellular Location||Nucleus. Chromosome.|
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Histones are basic nuclear proteins that are responsiblefor the nucleosome structure of the chromosomal fiber ineukaryotes. This structure consists of approximately 146 bp of DNAwrapped around a nucleosome, an octamer composed of pairs of eachof the four core histones (H2A, H2B, H3, and H4). The chromatinfiber is further compacted through the interaction of a linkerhistone, H1, with the DNA between the nucleosomes to form higherorder chromatin structures. This gene is intronless and encodes amember of the histone H3 family. Transcripts from this gene lackpolyA tails; instead, they contain a palindromic terminationelement. This gene is found in a histone cluster on chromosome 1.This gene is one of four histone genes in the cluster that areduplicated; this record represents the telomeric copy. [provided byRefSeq].
Neumann, H., et al. Mol. Cell 36(1):153-163(2009)Hurd, P.J., et al. J. Biol. Chem. 284(24):16575-16583(2009)Yuan, J., et al. Cell Cycle 8(11):1747-1753(2009)Chang, Q., et al. J. Hepatol. 50(2):323-333(2009)Kobza, K., et al. BMB Rep 41(4):310-315(2008)
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