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Mes-4 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9NH52
Clone Names 50908381
Additional Information
Gene ID 179824
Other Names Histone-lysine N-methyltransferase mes-4, Maternal-effect sterile protein 4, mes-4
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1965b was selected from the C-term region of human Mes-4. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name mes-4
Function Histone methyltransferase. Dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40- cell stage. Indirectly involved in the global inactivation of the X chromosomes in germline cells, possibly by excluding the mes-2- mes-3-mes-6 repressive Polycomb complex from the autosomes (PubMed:12077420, PubMed:16968818). Not related to transcription elongation (PubMed:12077420, PubMed:16968818). Required for small- RNA-induced H3K27 trimethylation (PubMed:26365259).
Cellular Location Nucleus. Chromosome. Note=Specifically associated with the autosomes and with the distal tip of chromosome X. Colocalizes with methylated 'Lys-4' of histone H3
Tissue Location In adults, it is predominantly expressed in the germline, and weakly expressed in intestinal cells
Research Areas
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Background

Mes-4 is a histone methyltransferase. This protein dimethylates 'Lys-36' of histone H3, a specific tag for epigenetic transcriptional activation. Mes-4 plays a central role in early development and is responsible for all H3 'Lys-36' dimethylation until about the 40-cell stage. It appears to be indirectly involved in the global inactivation of the X chromosomes in germ line cells, possibly by excluding the mes-2-mes-3-mes-6 repressive Polycomb complex from the autosomes.

References

Bender L.B., et al. Development. 2006. 133:3907-3917.Fong Y, et al. Science. 2002. 296(5576):2235-8.Korf I, et al. Development. 1998. 125(13):2469-78. Kelly WG, et al. Development. 1998. 125(13):2451-6.Garvin C, et al. Genetics. 1998. 148(1):167-85.

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$ 80.00
Cat# BP1965b
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