|Other Names||BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.|
|Tissue Location||Expressed in breast epithelial cell lines.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene was identified by itsability to bind to the nuclear localization signal of BRCA1 andother proteins. It is a cytoplasmic protein which may regulatenuclear targeting by retaining proteins with a nuclear localizationsignal in the cytoplasm.
Fulcher, A.J., et al. FASEB J. 24(5):1454-1466(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Hinohara, K., et al. J. Hum. Genet. 54(11):642-646(2009)Cui, R., et al. Gastroenterology 137(5):1768-1775(2009)
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