|Other Names||BRCA1-associated protein, 632-, BRAP2, Impedes mitogenic signal propagation, IMP, RING finger protein 52, Renal carcinoma antigen NY-REN-63, BRAP (HGNC:1099), RNF52|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto- polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.|
|Tissue Location||Expressed in breast epithelial cell lines.|
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The protein encoded by this gene was identified by itsability to bind to the nuclear localization signal of BRCA1 andother proteins. It is a cytoplasmic protein which may regulatenuclear targeting by retaining proteins with a nuclear localizationsignal in the cytoplasm.
Fulcher, A.J., et al. FASEB J. 24(5):1454-1466(2010)Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)Hinohara, K., et al. J. Hum. Genet. 54(11):642-646(2009)Cui, R., et al. Gastroenterology 137(5):1768-1775(2009)
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